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After the original description of the effects of MPTP on the dopamine-producing cells of the substantia nigra, a number of other environmental neurotoxins were described that can contribute to the development of parkinsonian symptoms.

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Cases of retroperitoneal fibrosis, pulmonary infiltrates, pleural effusion, pleural thickening, pericarditis, and cardiac valvulopathy have been reported in patients treated with ergot-derived dopaminergic agents.

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The process for the preparation of the dihydrochloride salt of the compound of formula I involves the propylation reaction of the compound of formula II with n-propanal as a propylating agent by using a mixture of methanol and water as the solvent.

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Gross RD, Atwood CW, Ross SB, Eichhorn KA, Olszewski JW, Doyle PJ: The coordination of breathing and swallowing in Parkinson's disease.

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Antiseizure drugs -- such as gabapentin (Neurontin), valproic acid (valproate, divalproex, Depakote, Depakene), and carbamazepine (Tegretol) are being tested for restless legs syndrome (RLS).

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That finding suggests that worsening of the condition is caused by dopamine agonists, not a natural occurrence, the study authors pointed out.

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