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Cryptococcus neoformans is another CNS opportunistic infection that has become rare among individuals receiving effective antiretroviral therapy.

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When efavirenz binds to CYP46A1 at the site shown in orange, it increases the flexibility of the protein in the region (magenta) around cholesterol (green).

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Association of noncirrhotic portal hypertension in HIV-infected persons and antiretroviral therapy with didanosine: a nested case-control study.

In addition to appropriate induction antifungal therapy for cryptococcal meningitis, immediate management of elevated intracranial pressure can markedly improve patient outcomes.

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Efavirenz Used for Prevention of Mother-to-Child Transmission of HIV in Botswana.

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BACKGROUND: Many trials of antiretroviral therapy in treatment-naïve subjects have investigated the relative efficacy of the third drug in a treatment regimen.

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EFV demonstrated antiviral activity against most non-clade B isolates (subtypes A, AE, AG, C, D, F, G, J, N), but had reduced antiviral activity against group O viruses.

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Using STIs composed of shorter cycles (eg, 1 week on, 1 week off) or guided by CD4 count or viral load parameters, other investigators have shown that these types of intermittent therapy may be able to reduce drug toxicity, reduce time on drug, reduce cost, and improve quality of life without sacrificing clinical control of HIV.

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This antiretroviral drug is used in combination with other antiretroviral agents for the treatment of HIV-1 infection.

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She also served as the principal investigator of an R24 mentoring grant from the NIH focused on nurturing early career investigators of diversity in HIV research, is the co-Director for the Center for AIDS Research (CFAR) Mentoring Program, and is the Chair of the Advisory Board for the UCSF Building Interdisciplinary Research Careers in Women's Health (BIRCWH).

Emtricitabine and tenofovir are principally eliminated by the kidney; however, efavirenz is not.

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Lipodystrophy, or "lipo" for short, is a collection of body shape changes in people taking antiretroviral medications (ARVs).

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