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What is the difference between Prilosec and Protonix? Protonix (pantoprazole) Treats heartburn and excess release of stomach acid. Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term. Treats heartburn and excess release of stomach acid.
Is a PPI considered an antacid? Proton pump inhibitors (PPIs) reduce your body's production of acid. They work well for heartburn that isn't resolved by antacids or H2 blockers. Omeprazole (brand name: Prilosec) and lansoprazole (brand name: Prevacid 24HR) are examples of OTC PPIs.
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