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Medication: Hyperthyroidism can be treated with the oral drug Tapazol (methimazole).

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Although there have been reports of hepatotoxicity (including acute liver failure) associated with Tapazole, the risk of hepatotoxicity appears to be less with methimazole than with propylthiouracil, especially in the pediatric population.

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The new Boxed Warning and Risk Evaluation and Mitigation Strategy (REMS), are based on FDA's review of post-marketing safety reports of propylthiouracil, as well as meetings held with the American Thyroid Association, the National Institute of Child Health and Human Development, and the pediatric endocrine clinical community.

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