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I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk.

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Methotrexate is wonderful for my severe rheumatoid arthritis. Without it I couldn't move neither hands, nor my legs. I was like a motionless statue. Now I feel normal and people cannot believe that I have RA. What's more the delivery service on this website is awesome - several days and you've got your order in your hands! Thanks.

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Caution should be taken when using LIVALO in combination with other cholesterol drugs like niacin and fibrates, as this may increase your risk of serious muscle problems.

Women should be warned that there may be a small increased risk of spontaneous abortion early in pregnancy, and advised against taking MTX if they are considering conception.

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Review of role of liver biopsy in monitoring methotrexate hepatotoxicity in patients with psoriasis and rheumatoid arthritis; PIIIP levels may provide a means of reducing number of biopsies, restricting surveillance biopsies to patients with high risk of having fibrosis).

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Use of higher doses of methotrexate in 21 children with severe juvenile rheumatoid arthritis was beneficial in only 33% of patients; transient ALT or AST elevations occurred in 38% and all resolved with holding dose, not requiring permanent discontinuation).

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Meta-analysis has revealed the incidence of progression of liver disease (worsening of 1 grade on the histologic classification of Roenigk) in patients with RA or psoriatic arthritis averages 27%, or 7% per gram of MTX (total dose) given.

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Dose range 50 units 3 times daily to 100 units daily, in a single or divided doses.

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It is not necessary for drugs to cross the placenta in order to exert a teratogenic effect, although MTX is known to pass to the fetus, even after maternal intrathecal administration.

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Low-dose weekly methotrexate (MTX) is widely used in the treatment of rheumatoid arthritis and is now increasingly used in other rheumatic conditions, including systemic lupus erythematosus and juvenile arthritis.

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Do not drive a car or operate machinery until you know how this medication affects you.

Using methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system).

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Methotrexate should not be taken if you are pregnant or plan to become pregnant.

It's not clear how Trexall treats rheumatoid arthritis, but it's believed the drug decreases the activity of the immune system.

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Methotrexate is indicated in the management of selected adults with severe, active, rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis, who have had an insufficient therapeutic response to, or are intolerant of, an adequate trial of first-line therapy including full dose nonsteroidal anti-inflammatory agents (NSAIDs).

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