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I have been taking the medication sine June 2011 I like it, but I'm always sick. It minimizes the pain and swelling, but it doesn't take it all away. I wake up every morning, and I can hardly move my ankles. I'm way to young to have to deal with this I'm only 22 years old. Some days I feel like I'm suffering, and if I'm sick I can't even walk.



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Methotrexate is wonderful for my severe rheumatoid arthritis. Without it I couldn't move neither hands, nor my legs. I was like a motionless statue. Now I feel normal and people cannot believe that I have RA. What's more the delivery service on this website is awesome - several days and you've got your order in your hands! Thanks.

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Women should be warned that there may be a small increased risk of spontaneous abortion early in pregnancy, and advised against taking MTX if they are considering conception.

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Review of role of liver biopsy in monitoring methotrexate hepatotoxicity in patients with psoriasis and rheumatoid arthritis; PIIIP levels may provide a means of reducing number of biopsies, restricting surveillance biopsies to patients with high risk of having fibrosis).

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Use of higher doses of methotrexate in 21 children with severe juvenile rheumatoid arthritis was beneficial in only 33% of patients; transient ALT or AST elevations occurred in 38% and all resolved with holding dose, not requiring permanent discontinuation).

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Meta-analysis has revealed the incidence of progression of liver disease (worsening of 1 grade on the histologic classification of Roenigk) in patients with RA or psoriatic arthritis averages 27%, or 7% per gram of MTX (total dose) given.

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It is not necessary for drugs to cross the placenta in order to exert a teratogenic effect, although MTX is known to pass to the fetus, even after maternal intrathecal administration.

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Low-dose weekly methotrexate (MTX) is widely used in the treatment of rheumatoid arthritis and is now increasingly used in other rheumatic conditions, including systemic lupus erythematosus and juvenile arthritis.

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It's not clear how Trexall treats rheumatoid arthritis, but it's believed the drug decreases the activity of the immune system.

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